The Griffins returned home as they hosted Gannon on Saturday afternoon in PSAC West play at DSG Field.
Gannon scored three times in the second half as they rallied for a 3-1 win over the Griffins.
SHU is currently in the fourth and final playoff spot with two contests remaining on the season.
Seton Hill took a 1-0 lead in the 21st minute off a corner kick.
Natalie Maver headed in a corner kick from
Maddie Teakle as Seton Hill took a 1-0 lead. SHU took the 1-0 lead into the halftime break.
Lindsey Pazdziorko made two saves in the half.
Gannon scored 2:31 into the second half as they tied the game at one. They added a second goal just six minutes later to take a 2-1 lead. They scored their final goal of the game with twenty minutes to play.
Pazdziorko finished with five saves in net.
SHU will close out the home portion of their schedule on Tuesday afternoon when they host Clarion.